Functionalized monolithic materials and mixed mode chromatography concepts: new materials and methods for amino acid, peptide as well as protein separation and analysis. Development and evaluation of new silica based polar and/or mixed modal stationary phases for hplc ph.d. Enantioselective separations utilizing zwitterionic chiral stationary phases master thesis, 2008 marek mahut. New analytical and preparative methods for plasmid dna separation and identification. Chemoselective derivatization of indoles for enrichment and subsequent analysis of tryptophan metabolites by hplc ms/ms. Synthesis and evaluation of new silica materials with different functionalities for chromatography. Development of selective tagging and trapping strategies directed to arginine and tryptophan residues in peptides using liquid chromatography and mass spectrometry.

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Novel organic and inorganic monolithic materials for microscale separation techniques. Analytical solutions to challenging problems in toxicology employing liquid phase separation concepts and mass spectrometry. Development and application of a spe hplc method for the determination of ochratoxin a in wine.

Development of concepts for the separation and racemisation of enantiomers of chiral acids. Development of alternative high performance liquid chromatographic peptide purification concepts and mixed mode reversed phase/ion exchange type adsorption materials. Development of an affinity chromatography method for igg type antibody purification with emphasis on immobilisation strategies and material characterisation. Synthesis and evaluation of chemically functionalized silica monoliths for high performance liquid chromatography.

Stereoselective peptide analysis: bridging of molecular recognition, liquid phase separation systems and mass spectrometry. Dedicated molecularly imprinted polymers for solid phase extraction of the mycotoxin ochratoxin a from red wine samples. Isolation and derivatization of alpha,beta unsaturated carbonylic compounds from plant oil and investigations on hybrid rp type stationary phases with electron donor/acceptor systems. Development and applications of novel recognition concepts for arginine residues in peptides and proteins using mass spectrometry. Development of novel strong cation exchangers for separation of chiral bases by capillary electrochromatography. Development of a selective separation method directed towards arginine/guanidine in combination with liquid chromatography/mass spectrometry.

Synthesis and evaluation of a novel class of epiaminoquinine based chiral stationary phases. Development of novel chiral selectors based on cinchona scaffolds using combinatorial chemistry approaches. Stereoselective capillary electrochromatography: development of novel chiral stationary phases and their application for enantiomeric impurity profiling.

Development and optimization of enantioselective separation systems for analysis of ionic compounds by hplc, ce and cec. Analysis of ochratoxin a in wine by lc fluorescence detection using a combination of rp 18 and mip solid phase extraction materials for sample preparation. Master thesis, 2002 helmut hinterwirth : tba master thesis georg schuster : tba ph.d. Thesis andrea gargano : tba master thesis roland reischl. Separation and quantitation of metabolites in biological systems by liquid chromatography and tandem mass spectrometry ph.d. Thesis alexander ronache r: development and evaluation of new artificial ligands for antibody analysis and purification. Development and evaluation of silica based mixed mode weak and strong ion exchangers including their applications in bioanalytics.

Selective trapping, labelling and immobilisation concepts of amino acids, peptides, proteins and drug compounds in the course of lc ms analysis ph.d. Development of chromatographic materials and artificial ligands for protein and antibody analysis and purification. And master theses are regularly offered from the range of research topics pursued by prof. The individual topic of the thesis depends on the current status of the ongoing studies and the interests of the candidate. The theses often involve i the use of lc ms technologies, ii synthesis steps in the course of materials development and i the utilization of diverse analytical methods for the characterization of the materials.